The Cuyín Manzano River, also called Cuyín Manzano Stream, is a short stream located in the southwest of Neuquén Province, in the Argentinean Patagonia.
Its name means "old apple tree" in Mapuche language.
It is entirely located in the Nahuel Huapi National Park, and runs through a narrow valley, sorrounded by cypresses and maitenes, as well as areas of steppe.